Article

The IRE1α/XBP1 signaling axis drives myoblast fusion in adult skeletal muscle

2023-09-27

Abstract excerpt

<h4>ABSTRACT</h4> Skeletal muscle regeneration involves a signaling network that regulates the proliferation, differentiation, and fusion of muscle precursor cells to injured myofibers. Inositol requiring enzyme 1 alpha (IRE1α) is one of the arms of the unfolded protein response (UPR) that regulates cellular proteostasis in response to ER stress. Here, we demonstrate that inducible deletion of IRE1α in adult musc...

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Literature Corpus work: ddbcab84-6f40-5be6-a52a-9f6beb4d5e49
DOI: 10.1101/2023.09.26.559625

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