Polymorphisms in epidermal growth factor receptor (EGFR) and AKT1 as possible predictors of clinical outcome in advanced non-small-cell lung cancer patients treated with EGFR tyrosine kinase inhibitors.

doi:10.1007/s13277-015-3893-1

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Article

Polymorphisms in epidermal growth factor receptor (EGFR) and AKT1 as possible predictors of clinical outcome in advanced non-small-cell lung cancer patients treated with EGFR tyrosine kinase inhibitors.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2016

Zhang Xiaoqing, Fan Junwei, Li Yuping, Lin Shengtao, Shu Ping, Ni Jian, Qin Shengying, Zhang Zhemin

Abstract excerpt

This study aimed to investigate the association of epidermal growth factor receptor (EGFR) gene polymorphism and AKT1 polymorphism with the clinical outcomes in advanced non-small cell lung cancer (NSCLC) patients treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs). The clinical outcome and the survival of NSCLC of 230 patients after treatment with EGFR-TKIs were measured. The rs712829, rs1468727 of the EGFR...

Topics

Adult
Aged
Aged, 80 and over
Antineoplastic Agents
Carcinoma, Non-Small-Cell Lung
ErbB Receptors
Female

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Kaplan-Meier Estimate

Lung Neoplasms

Male

Middle Aged

Molecular Targeted Therapy

Mutation

Neoplasm Staging

Polymorphism, Single Nucleotide

Prognosis

Source

Open in PubMed

Identifiers

PMID: 26269114
DOI: 10.1007/s13277-015-3893-1

Genes

EGFR
AKT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.