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Article

DNA repair gene polymorphisms predict favorable clinical outcome in advanced non-small-cell lung cancer.

Clinical lung cancer - 1 Mar 2009

Kalikaki Aristea, Kanaki Maria, Vassalou Helen, Souglakos John, Voutsina Alexandra, Georgoulias Vassilis, Mavroudis Dimitris

Abstract excerpt

BACKGROUND: Genetic polymorphisms of genes involved in DNA repair and glutathione metabolic pathways may affect patients' response to platinum-based chemotherapy. We retrospectively assessed whether single nucleotide polymorphisms (SNP) of DNA-repair genes ERCC1, XPD, XRCC1 and glutathione S-transferase genes GSTP1, GSTT1 and GSTM1 predict overall survival (OS), response and toxicity in 119 non-small-cell lung...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19362955
DOI: 10.3816/CLC.2009.n.015

Genes

ERCC1
XRCC1
GSTM1
GSTP1
GSTT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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