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Article

Heritability in the efficiency of nonsense-mediated mRNA decay in humans.

PloS one - 21 Jul 2010

Seoighe Cathal, Gehring Chris

Abstract excerpt

BACKGROUND: In eukaryotes mRNA transcripts of protein-coding genes in which an intron has been retained in the coding region normally result in premature stop codons and are therefore degraded through the nonsense-mediated mRNA decay (NMD) pathway. There is evidence in the form of selective pressure for in-frame stop codons in introns and a depletion of length three introns that this is an important and conserved...

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Identifiers

PMID: 20657766
DOI: 10.1371/journal.pone.0011657
PMCID: PMC2908117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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