Article

Epistasis and destabilizing mutations shape gene expression variability in humans via distinct modes of action

2015-09-09

Abstract excerpt

Increasing evidence shows that, like phenotypic mean, phenotypic variance is also genetically determined, but the underlying mechanisms of genetic control over the variance remain obscure. Here, we conducted variance-association mapping analyses to identify expression variability QTLs (evQTLs), i.e., genomic loci associated with gene expression variance, in humans. We discovered that common genetic variations may...

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Literature Corpus work: 7a6fca2b-0a23-586c-9467-24c8b4dfc052
DOI: 10.1101/026393

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