High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE.

doi:10.1111/j.1752-8062.2012.00446.x

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Article

High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE.

Clinical and translational science - 1 Oct 2012

Rasmussen-Torvik Laura J, Pacheco Jennifer A, Wilke Russell A, Thompson William K, Ritchie Marylyn D, Kho Abel N, Muthalagu Arun, Hayes M Geoff, Armstrong Loren L, Scheftner Douglas A, Wilkins John T, Zuvich Rebecca L, Crosslin David, Roden Dan M, Denny Joshua C, Jarvik Gail P, Carlson Christopher S, Kullo Iftikhar J, Bielinski Suzette J, McCarty Catherine A, Li Rongling, Manolio Teri A, Crawford Dana C, Chisholm Rex L

Abstract excerpt

Only one low-density lipoprotein cholesterol (LDL-C) genome-wide association study (GWAS) has been previously reported in -African Americans. We performed a GWAS of LDL-C in African Americans using data extracted from electronic medical records (EMR) in the eMERGE network. African Americans were genotyped on the Illumina 1M chip. All LDL-C measurements, prescriptions, and diagnoses of concomitant disease were...

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Identifiers

PMID: 23067351
DOI: 10.1111/j.1752-8062.2012.00446.x
PMCID: PMC3521536

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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