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Article

A large electronic-health-record-based genome-wide study of serum lipids.

Nature genetics - 1 Mar 2018

Hoffmann Thomas J, Theusch Elizabeth, Haldar Tanushree, Ranatunga Dilrini K, Jorgenson Eric, Medina Marisa W, Kvale Mark N, Kwok Pui-Yan, Schaefer Catherine, Krauss Ronald M, Iribarren Carlos, Risch Neil

Abstract excerpt

A genome-wide association study (GWAS) of 94,674 ancestrally diverse Kaiser Permanente members using 478,866 longitudinal electronic health record (EHR)-derived measurements for untreated serum lipid levels empowered multiple new findings: 121 new SNP associations (46 primary, 15 conditional, and 60 in meta-analysis with Global Lipids Genetic Consortium data); an increase of 33-42% in variance explained with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29507422
DOI: 10.1038/s41588-018-0064-5
PMCID: PMC5942247

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ABO
FUT2

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