Article
A polymorphism in the 3'-untranslated region of the NPM1 gene causes illegitimate regulation by microRNA-337-5p and correlates with adverse outcome in acute myeloid leukemia.
Haematologica - 1 Jun 2013
Cheng Chi Keung, Kwan Tsz Ki, Cheung Chi Ying, Ng Kitty, Liang Pei, Cheng Suk Hang, Chan Natalie P H, Ip Rosalina K L, Wong Raymond S M, Lee Vincent, Li Chi Kong, Yip Sze Fai, Ng Margaret H L
Abstract excerpt
Nucleophosmin, encoded by NPM1, is a haploinsufficient suppressor in hematologic malignancies. NPM1 mutations are mostly found in acute myeloid leukemia patients with normal karyotype and associated with favorable prognosis. A polymorphic nucleotide T deletion with unknown significance is present in the NPM1 3'-untranslated region. Here, we showed that the homozygous nucleotide T deletion was associated with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.