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Article

Functional invariant natural killer T-cell and CD1d axis in chronic lymphocytic leukemia: implications for immunotherapy.

Haematologica - 1 Mar 2013

Weinkove Robert, Brooks Collin R, Carter John M, Hermans Ian F, Ronchese Franca

Abstract excerpt

Invariant natural killer T cells recognize glycolipid antigens such as α-galactosylceramide presented by CD1d. In preclinical models of B-cell malignancies, α-galactosylceramide is an adjuvant to tumor vaccination, enhancing tumor-specific T-cell responses and prolonging survival. However, numerical and functional invariant natural killer T-cell defects exist in patients with some cancers. Our aim was to assess...

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Share to Antigens, CD1d
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

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Identifiers

PMID: 23065503
DOI: 10.3324/haematol.2012.072835
PMCID: PMC3659950

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