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Article

Osteonecrosis of the Jaw and the Role of Macrophages

28 Dec 2010

Abstract excerpt

Nitrogen-containing bisphosphonates have been associated with the development of osteonecrosis of the jaws (ONJ), but the lack of reliable epidemiological data and appropriate animal models has restricted our understanding of ONJ pathophysiology and limited its management. The best available information is from histopathologic findings, which implicate bone necrosis and infection, although it is not clear which...

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PMID: 21189409
DOI: 10.1093/jnci/djq516

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