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Article

Bu‑Shen‑Ning‑Xin decoction suppresses osteoclastogenesis by modulating RANKL/OPG imbalance in the CD4+ T lymphocytes of ovariectomized mice.

International journal of molecular medicine - 1 Jul 2018

Zhang Jia-Li, Qiu Xue-Min, Zhang Na, Tang Wei, Gober Hans-Jürgen, Li Da-Jin, Wang Ling

Abstract excerpt

Postmenopausal osteoporosis (PMO) has been recognized as an inflammatory condition. CD4+ T cells serve a key role in the interaction between bone metabolism and the immune system. Bu‑Shen‑Ning‑Xin decoction (BSNXD), a traditional Chinese medicine, has been ultilized as a remedy for PMO. In the present study, the aim was to investigate the immune modulatory effects of BSNXD on CD4+ T cells, receptor activation of...

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Identifiers

PMID: 29717766
DOI: 10.3892/ijmm.2018.3645
PMCID: PMC5979942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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