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Article

Bisphosphonate-associated osteonecrosis of the jaw: a key role of inflammation?

Bone - 1 Nov 2009

Lesclous Philippe, Abi Najm Semaan, Carrel Jean-Pierre, Baroukh Brigitte, Lombardi Tommaso, Willi Jean-Pierre, Rizzoli René, Saffar Jean-Louis, Samson Jacky

Abstract excerpt

Osteonecrosis of the jaw (ONJ) can be associated with nitrogen-containing bisphosphonates (NBPs) therapy. Various mechanisms of NBP-associated ONJ have been proposed and there is currently no consensus of the underlying pathogenesis. The detailed medical and dental histories of 30 ONJ patients treated with NBPs for malignant diseases (24) or osteoporosis (6) were analyzed. The necrotic bone was resected and...

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Apoptosis
Diphosphonates
Follow-Up Studies
Inflammation
Necrosis

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PMID: 19631301
DOI: 10.1016/j.bone.2009.07.011

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