Article
Differential impact of cumulative SES risk on methylation of protein-protein interaction pathways as a function of SLC6A4 genetic variation in African American young adults.
Biological psychology - 1 Feb 2014
Beach Steven R H, Dogan Meeshanthini V, Brody Gene H, Philibert Robert A
Abstract excerpt
Exposure to cumulative SES risk in childhood may interact with variability at the serotonin transporter linked polymorphic region (5HTTLPR) to alter DNA methylation across interacting sets of proteins. DNA was obtained from 388 African Americans at age 19. Genotype at the 5HTTLPR was determined, and methylation ratios for C-phosphate-G (CpG) residues were assessed. Exposure to cumulative SES risk was determined...
Topics
- Black or African American
- Caregivers
- DNA Methylation
- Female
- Follow-Up Studies
- Gene-Environment Interaction
- Genetic Variation
- Genotype
- Humans
- Male
- Protein Interaction Maps