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Article

Associations between maternal genotypes and metabolites implicated in congenital heart defects.

Molecular genetics and metabolism - 1 Nov 2012

Chowdhury Shimul, Hobbs Charlotte A, MacLeod Stewart L, Cleves Mario A, Melnyk Stepan, James S Jill, Hu Ping, Erickson Stephen W

Abstract excerpt

BACKGROUND: The development of non-syndromic congenital heart defects (CHDs) involves a complex interplay of genetics, metabolism, and lifestyle. Previous studies have implicated maternal single nucleotide polymorphisms (SNPs) and altered metabolism in folate-related pathways as CHD risk factors. OBJECTIVE: We sought to discover associations between maternal SNPs and metabolites involved in the homocysteine,...

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Identifiers

PMID: 23059056
DOI: 10.1016/j.ymgme.2012.09.022
PMCID: PMC3523122

Genes

MGMT
CAT
GPX6
MTHFS
TRDMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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