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Maternal DNA hypomethylation and congenital heart defects

19 Jan 2011

Abstract excerpt

BACKGROUND: Congenital heart defects (CHDs) are among the most prevalent and serious of birth defects. Multiple maternal factors are thought to contribute to CHD development, including folate intake. Maternal DNA methylation, which is dependent on folate metabolism, may impact the risk of CHDs. Our study was designed to determine whether maternal long interspersed nucleotide elements-1 (LINE-1) DNA...

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PMID: 21254366
DOI: 10.1002/bdra.20761

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