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Article

Expression and significance of histone H3K27 demethylases in renal cell carcinoma

12 Oct 2012

Abstract excerpt

BACKGROUND: The histone H3K27 demethylases UTX and JMJD3 are important regulatory factors that modulate gene expression by altering the physical state of chromatin. Previous studies have indicated an abnormal H3K27 methylation status in carcinogenesis. We therefore investigated the expression patterns of UTX and JMJD3 in renal cell carcinoma (RCC) and their roles in cancer development. METHODS: The mRNA...

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PMID: 23057811
DOI: 10.1186/1471-2407-12-470

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