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Fluoroquinolone resistance in Streptococcus pneumoniae from a university hospital, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet - 1 Nov 2010

Srifuengfung Somporn, Tribuddharat Chanwit, Chokephaibulkit Kulkanya, Comerungsee Sopita

Abstract excerpt

The most frequent markers of fluoroquinolone resistance in S. pneumoniae are chromosomal mutations in the quinolone-resistance-determining regions of DNA gyrase and topoisomerase IV encoding for the gyrA, gyrB and parC, parE genes. In 2008, 6.5% of the Streptococcus pneumoniae isolates in a Bangkok university hospital were resistant to ofloxacin. Using PCR and DNA sequencing, we identified mutations in both the...

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PMID: 21298832

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