Article
Impact on quinolone resistance of plasmid-mediated quinolone resistance gene and mutations in quinolone resistance-determining regions in extended spectrum beta lactamase-producing Klebsiella pneumoniae isolated from urinary tract infection patients.
Pathogens and disease - 17 Aug 2022
Onishi Reo, Shigemura Katsumi, Osawa Kayo, Yang Young-Min, Maeda Koki, Tanimoto Hiroshi, Kado Mitsuki, Fang Shiuh-Bin, Sung Shian-Ying, Miyara Takayuki, Fujisawa Masato
Abstract excerpt
Klebsiella pneumoniae is a typical pathogen in urinary tract infections (UTI), and the emergence of extended spectrum beta-lactamase (ESBL)-producing strains has been frequently reported, accompanied by higher quinolone resistance rates. There are two major mechanisms of quinolone resistance, mutations in quinolone resistance-determining regions (QRDR) and the presence of the plasmid-mediated quinolone resistance...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Drug Resistance, Bacterial
- Humans
- Klebsiella pneumoniae
- Microbial Sensitivity Tests
- Mutation
- Plasmids
- Quinolones