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Article

Elevated HTRA1 and HTRA4 in severe preeclampsia and their roles in trophoblast functions

16 Jul 2018

Abstract excerpt

Aberrant gene expression during placental development may affect fetal growth and contribute to preeclampsia. The high‑temperature requirement A (HTRA) family of proteins are serine proteases that may serve in the quality control of misfolded or mislocalized proteins. Recently, the potential involvement of HTRA1 and HTRA4 in the normal development of the placenta and in the pathogenesis of preeclampsia has been...

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PMID: 30015931
DOI: 10.3892/mmr.2018.9289

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