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Article

In vivo knockdown of intersectin-1s alters endothelial cell phenotype and causes microvascular remodeling in the mouse lungs.

Apoptosis : an international journal on programmed cell death - 1 Jan 2013

Bardita Cristina, Predescu Dan, Justice Matthew J, Petrache Irina, Predescu Sanda

Abstract excerpt

Intersectin-1s (ITSN-1s) is a general endocytic protein involved in regulating lung vascular permeability and endothelial cells (ECs) survival, via MEK/Erk1/2(MAPK) signaling. To investigate the in vivo effects of ITSN-1s deficiency and the resulting ECs apoptosis on pulmonary vasculature and lun...

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Identifiers

PMID: 23054079
DOI: 10.1007/s10495-012-0762-x
PMCID: PMC3543613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23054079-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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