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Article

E-cadherin promotor methylation and mutation are inversely related to motility capacity of breast cancer cells.

Breast cancer research and treatment - 1 Nov 2012

van Horssen Remco, Hollestelle Antoinette, Rens Joost A P, Eggermont Alexander M M, Schutte Mieke, Ten Hagen Timo L M

Abstract excerpt

Inactivation of the tumor suppressor E-cadherin is an important event during breast tumorigenesis, as its decreased expression is linked to aggressiveness and metastasis. However, the relationship between the different modes of E-cadherin inactivation (mutation versus promotor hypermethylation) and breast cancer cell behavior is incompletely understood. The high correlation between E-cadherin inactivation status...

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Source

Identifiers

PMID: 23053649
DOI: 10.1007/s10549-012-2261-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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