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Silent information regulator, Sirtuin 1, and age‐related diseases

23 Feb 2009

Abstract excerpt

Sirtuin 1 (SIRT1), a member of the silent information regulator 2 in mammals, has recently been found to be involved in age-related diseases, such as cancer, metabolic diseases, cardiovascular disease, neurodegenerative diseases, osteoporosis and chronic obstructive pulmonary disease (COPD), mainly through deacetylation of substrates such as p53, forkhead box class O, peroxisome proliferator activated receptor...

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PMID: 19260974
DOI: 10.1111/j.1447-0594.2008.00504.x

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