Article
Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells.
BMC biotechnology - 10 Oct 2012
Sumitomo Yasuhiko, Higashitsuji Hiroaki, Higashitsuji Hisako, Liu Yu, Fujita Takanori, Sakurai Toshiharu, Candeias Marco M, Itoh Katsuhiko, Chiba Tsutomu, Fujita Jun
Abstract excerpt
BACKGROUND: There are a growing number of reports on the sub-physiological temperature culturing of mammalian cells for increased recombinant protein yields. However, the effect varies and the reasons for the enhancement are not fully elucidated. Expression of cold-inducible RNA-binding protein (cirp, also called cirbp or hnRNP A18) is known to be induced in response to mild, but not severe, hypothermia in...
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