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Regulation of CIRP by genetic factors of SP1 related to cold sensitivity

16 Sept 2022

Abstract excerpt

Cold-inducible RNA-binding-protein (CIRP) is a cold shock protein that plays a protective role in genotoxic stress response. CIRP modulates inflammation in human diseases, inhibits cell proliferation, and protects cells from genotoxic damage during cellular stress. The mild cold responsive element and specificity protein 1 (SP1) play a role in Cirp expression at low temperatures. Although previous studies have...

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PMID: 36189232
DOI: 10.3389/fimmu.2022.994699

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