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Article

Identification of a novel temperature sensitive promoter in CHO cells.

BMC biotechnology - 12 May 2011

Thaisuchat Haruthai, Baumann Martina, Pontiller Jens, Hesse Friedemann, Ernst Wolfgang

Abstract excerpt

BACKGROUND: The Chinese hamster ovary (CHO) expression system is the leading production platform for manufacturing biopharmaceuticals for the treatment of numerous human diseases. Efforts to optimize the production process also include the genetic construct encoding the therapeutic gene. Here we report about the successful identification of an endogenous highly active gene promoter obtained from CHO cells which...

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Identifiers

PMID: 21569433
DOI: 10.1186/1472-6750-11-51
PMCID: PMC3118111

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