Article
Somatic mosaicism for copy number variation in differentiated human tissues.
Human mutation - 1 Sept 2008
Piotrowski Arkadiusz, Bruder Carl E G, Andersson Robin, Diaz de Ståhl Teresita, Menzel Uwe, Sandgren Johanna, Poplawski Andrzej, von Tell Desiree, Crasto Chiquito, Bogdan Adam, Bartoszewski Rafal, Bebok Zsuzsa, Krzyzanowski Maciej, Jankowski Zbigniew, Partridge E Christopher, Komorowski Jan, Dumanski Jan P
Abstract excerpt
Two major types of genetic variation are known: single nucleotide polymorphisms (SNPs), and a more recently discovered structural variation, involving changes in copy number (CNVs) of kilobase- to megabase-sized chromosomal segments. It is unknown whether CNVs arise in somatic cells, but it is, however, generally assumed that normal cells are genetically identical. We tested 34 tissue samples from three subjects...
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