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Article

DNA interaction of the CcrM DNA methyltransferase: a mutational and modeling study.

Chembiochem : a European journal of chemical biology - 18 Jun 2012

Albu Razvan F, Zacharias Martin, Jurkowski Tomasz P, Jeltsch Albert

Abstract excerpt

Caulobacter crescentus CcrM is a DNA-(adenine N6)-methyltransferase that methylates adenine in the sequence GANTC with high specificity. To investigate its mechanism of DNA recognition, we used the crystal structure of a related methyltransferase (M1.MboII, which modifies GAAGA) as a starting point, and docked into it a DNA substrate to identify the protein regions that approach the DNA. After alignment of CcrM...

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Identifiers

PMID: 22639453
DOI: 10.1002/cbic.201200082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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