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Generation of ovarian follicles from mouse pluripotent stem cells

15 Jul 2021

Abstract excerpt

Oocytes mature in a specialized fluid-filled sac, the ovarian follicle, which provides signals needed for meiosis and germ cell growth. Methods have been developed to generate functional oocytes from pluripotent stem cell-derived primordial germ cell-like cells (PGCLCs) when placed in culture with embryonic ovarian somatic cells. In this study, we developed culture conditions to recreate the stepwise...

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PMID: 34437124
DOI: 10.1126/science.abe0237

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