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Generation of Functional Oocytes and Spermatids from Fetal Primordial Germ Cells after Ectopic Transplantation in Adult Mice

10 Nov 2010

Abstract excerpt

Primordial germ cells (PGCs) are undifferentiated germ cells in developing fetuses. As these cells give rise to definitive oocytes and spermatozoa that contribute to new life in the next generation, their development must be under strict control, regarding genetic and epigenetic aspects. However, we do not know to what extent their development depends on the specific milieu. In this study, we transplanted mouse...

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PMID: 21076079
DOI: 10.1095/biolreprod.110.087122

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