Article
Lack of association between PICALM rs3851179 polymorphism and Alzheimer's disease in Chinese population and APOEε4-negative subgroup.
Neurobiology of aging - 1 Apr 2013
Liu Guiyou, Zhang Liangcai, Feng Rennan, Liao Mingzhi, Jiang Yongshuai, Chen Zugen, Zhao Bin, Li Keshen
Abstract excerpt
Recently, the association between PICALM rs3851179 polymorphism and Alzheimer's disease (AD) was investigated in the Chinese population by 3 independent studies. However, both allele and genotype tests failed to reveal any association. The association was identified only in the APOEε4-negative subgroup. We think that the failure to replicate the association may be because of the relatively small sample size. In...
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