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Article

A bacterial pathogen co-opts host plasmin to resist killing by cathelicidin antimicrobial peptides.

The Journal of biological chemistry - 30 Nov 2012

Hollands Andrew, Gonzalez David, Leire Emma, Donald Cortny, Gallo Richard L, Sanderson-Smith Martina, Dorrestein Pieter C, Nizet Victor

Abstract excerpt

The bacterial pathogen Group A Streptococcus (GAS) colonizes epithelial and mucosal surfaces and can cause a broad spectrum of human disease. Through the secreted plasminogen activator streptokinase (Ska), GAS activates human plasminogen into plasmin and binds it to the bacterial surface. The resulting surface plasmin protease activity has been proposed to play a role in disrupting tissue barriers, promoting...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23038245
DOI: 10.1074/jbc.M112.404582
PMCID: PMC3510793

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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