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Article

Trigger for group A streptococcal M1T1 invasive disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2006

Cole Jason N, McArthur Jason D, McKay Fiona C, Sanderson-Smith Martina L, Cork Amanda J, Ranson Marie, Rohde Manfred, Itzek Andreas, Sun Hongmin, Ginsburg David, Kotb Malak, Nizet Victor, Chhatwal G S, Walker Mark J

Abstract excerpt

The globally disseminated Streptococcus pyogenes M1T1 clone causes a number of highly invasive human diseases. The transition from local to systemic infection occurs by an unknown mechanism; however invasive M1T1 clinical isolates are known to express significantly less cysteine protease SpeB than M1T1 isolates from local infections. Here, we show that in comparison to the M1T1 strain 5448, the isogenic mutant...

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Identifiers

PMID: 16790522
DOI: 10.1096/fj.06-5804fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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