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Article

Pharmacological modulation of procoagulant microparticles improves haemodynamic dysfunction during septic shock in rats.

Thrombosis and haemostasis - 1 Jan 2014

Boisramé-Helms Julie, Delabranche Xavier, Degirmenci Su-Emmanuelle, Zobairi Fatiha, Berger Asael, Meyer Grégory, Burban Mélanie, Mostefai Hadj-Ahmed, Levy Bruno, Toti Florence, Meziani Ferhat

Abstract excerpt

Circulating microparticles play a pro-inflammatory and procoagulant detrimental role in the vascular dysfunction of septic shock. It was the objective of this study to investigate mechanisms by which a pharmacological modulation of microparticles could affect vascular dysfunction in a rat model of septic shock. Septic or sham rats were treated by activated protein C (aPC) and resuscitated during 4 hours. Their...

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PMID: 24108660
DOI: 10.1160/TH13-04-0313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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