Fixing the leak: targeting the vascular endothelium in sepsis.

Abstract excerpt

Angiopoietin-1 is a Tie-2 receptor agonist that stabilizes vascular endothelium, promoting endothelial maturation and preventing capillary leak. Angiopoietin-2 is largely a competitive partial antagonist that is markedly elevated in humans and animal models of sepsis and other inflammatory states, directly disrupts the endothelial barrier, and has been correlated with end-organ dysfunction and death in sepsis. In...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Angiopoietin-1
• Share to Disease Models, Animal
• Share to Genetic Variation