Article
Analysis of the role of 5' regulatory mutations in the activation of quiescent metallothionein genes after carcinogen treatment.
Gene expression - 1 Jan 1991
Aguilar-Cordova E, Lebovitz R M, Lieberman M W
Abstract excerpt
S49 are mouse thymic lymphoma cells which do not express the two closely linked mouse metallothionein (MT) genes; however, previous studies demonstrated that treatment of S49 cells with chemical carcinogens or ultraviolet irradiation can activate these quiescent genes. To determine if activation of MT-I or MT-II in these variants is a result of cis-acting mutations, we amplified and sequenced the immediate 5'...
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