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The Viral Class II Membrane Fusion Machinery: Divergent Evolution from an Ancestral Heterodimer

26 Nov 2021

Abstract excerpt

A key step during the entry of enveloped viruses into cells is the merger of viral and cell lipid bilayers. This process is driven by a dedicated membrane fusion protein (MFP) present at the virion surface, which undergoes a membrane-fusogenic conformational change triggered by interactions with the target cell. Viral MFPs have been extensively studied structurally, and are divided into three classes depending on...

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PMID: 34960636
DOI: 10.3390/v13122368

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