TCF7L2 genetic variants modulate the effect of dietary fat intake on changes in body composition during a weight-loss intervention.

doi:10.3945/ajcn.112.038125

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Article

TCF7L2 genetic variants modulate the effect of dietary fat intake on changes in body composition during a weight-loss intervention.

The American journal of clinical nutrition - 1 Nov 2012

Mattei Josiemer, Qi Qibin, Hu Frank B, Sacks Frank M, Qi Lu

Abstract excerpt

BACKGROUND: TCF7L2 gene variants have been associated with increased risk of type 2 diabetes and higher adiposity. Observational studies and short-term trials have suggested that macronutrients may modify these effects. However, to our knowledge, this has yet to be verified in long-term interventions. OBJECTIVE: In a long-term intervention setting, we investigated the effects of TCF7L2 polymorphisms rs7903146 and...

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Identifiers

PMID: 23034957
DOI: 10.3945/ajcn.112.038125
PMCID: PMC3471200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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