Article
Genetic susceptibility to diabetes and long-term improvement of insulin resistance and β cell function during weight loss: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.
The American journal of clinical nutrition - 1 Jul 2016
Huang Tao, Ley Sylvia H, Zheng Yan, Wang Tiange, Bray George A, Sacks Frank M, Qi Lu
Abstract excerpt
BACKGROUND: Diet interventions have shown effectiveness in improving diabetes risk factors; however, little is known about whether the effects of diet intervention are different according to genetic susceptibility. OBJECTIVE: We examined interactions between weight-loss diets and the genetic risk score (GRS) for diabetes on 2-y changes in markers of insulin resistance and β cell function in a randomized...
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