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Article

Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes.

Diabetes - 1 Mar 2010

Haupt Axel, Thamer Claus, Heni Martin, Ketterer Caroline, Machann Jürgen, Schick Fritz, Machicao Fausto, Stefan Norbert, Claussen Claus D, Häring Hans-Ulrich, Fritsche Andreas, Staiger Harald

Abstract excerpt

OBJECTIVE: The impact of the diabetes risk gene transcription factor 7-like 2 (TCF7L2) on body weight is unclear. As TCF7L2 is expressed in adipose tissue and involved in Wnt-dependent regulation of adipogenesis, we studied the impact of TCF7L2 variants on body composition and weight loss during lifestyle intervention. RESEARCH DESIGN AND METHODS: We genotyped 309 German subjects at increased risk for type 2...

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Share to Body Composition
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose Tolerance Test

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Share to Transcription Factor 7-Like 2 Protein

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Source

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Identifiers

PMID: 20028944
DOI: 10.2337/db09-1050
PMCID: PMC2828665

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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