Use of alternative promoters may hide genetic effects on phenotypic traits.

Abstract excerpt

Genome-wide association studies have identified a multitude of single-nucleotide polymorphisms (SNPs) associated with a wide spectrum of human phenotypic traits. However, the SNPs identified so far do not explain much of the expected genetic variation and they are poor predictors of the occurrence of disease. I recently advanced the hypothesis that there is person-to-person variation in the use of alternative...

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