Article
Increasing alternative promoter repertories is positively associated with differential expression and disease susceptibility.
PloS one - 1 Mar 2010
Liu Song
Abstract excerpt
BACKGROUND: Alternative Promoter (AP) usages have been shown to enable diversified transcriptional regulation of individual gene in a context-specific (e.g., pathway, cell lineage, tissue type, and development stage et. ac.) way. Aberrant uses of APs have been directly linked to mechanism of certain human diseases. However, whether or not there exists a general link between a gene's AP repertoire and its...
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