Article

Methyl deficiency, DNA methylation, and cancer: studies on the reversibility of the effects of a lipotrope-deficient diet

1993-12-01

Abstract excerpt

Methylation of C residues in CpG sites in the regulatory, regions of a wide variety of genes has been linked to silencing of their expression. During normal mammalian development, loss of methylation at specific sites accompanies tissue-specific activation of genes. Overall decreases in the level of DNA methylation and alterations in the pattern of methylation of specific genes are also closely linked to tumor dev...

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Literature Corpus work: 5cd51a60-b5eb-5c3e-8cb2-b44d54a5fe66
DOI: 10.1016/0955-2863(93)90106-7

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