Article
Sirolimus interacts with pathways essential for podocyte integrity.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Feb 2009
Letavernier Emmanuel, Bruneval Patrick, Vandermeersch Sophie, Perez Joelle, Mandet Chantal, Belair Marie-France, Haymann Jean-philippe, Legendre Christophe, Baud Laurent
Abstract excerpt
BACKGROUND: The specific mTor inhibitor sirolimus has been implicated in the pathogenesis of renal glomerular lesions and nephrotic syndrome appearance after transplantation. Podocyte injury and focal segmental glomerulosclerosis have been related to sirolimus therapy in some patients but the pathways underlying these lesions remain hypothetical. METHODS: To go further in the comprehension of these mechanisms,...
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