Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Limited evidence for parent-of-origin effects in inflammatory bowel disease associated loci.

PloS one - 1 Jan 2012

Fransen Karin, Mitrovic Mitja, van Diemen Cleo C, Thelma B K, Sood Ajit, Franke Andre, Schreiber Stefan, Midha Vandana, Juyal Garima, Potocnik Uros, Fu Jingyuan, Nolte Ilja, Weersma Rinse K

Abstract excerpt

BACKGROUND: Genome-wide association studies of two main forms of inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), have identified 99 susceptibility loci, but these explain only 23% of the genetic risk. Part of the 'hidden heritability' could be in transmissible genetic effects in which mRNA expression in the offspring depends on the parental origin of the allele (genomic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Butyrophilins
Share to Colitis, Ulcerative

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crohn Disease

Share to Genomic Imprinting

Share to Inheritance Patterns

Share to Interleukin-12 Subunit p40

Share to Nod2 Signaling Adaptor Protein

Share to Positive Regulatory Domain I-Binding Factor 1

Source

Open in PubMed Open full text

Identifiers

PMID: 23028907
DOI: 10.1371/journal.pone.0045287
PMCID: PMC3459955

Genes

NOD2
BTNL2
PRDM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Limited evidence for parent-of-origin effects in inflammatory bowel disease associated loci.PMID 23028907Read ↗

Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping.Semantic proximity Read ↗

Genome-wide survey of parent-of-origin specific associations across clinical traits derived from electronic health recordsSemantic proximity Read ↗

An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.Semantic proximity Read ↗

Prediction of Inflammatory Bowel Diseases using Genetic Risk Score in Asian populationsSemantic proximity Read ↗

Early Life and Childhood Environmental Exposures, More Than Genetic Predisposition, Influence Age of Diagnosis in a Diverse Cohort of 2952 Patients With IBD.Semantic proximity Read ↗

The role of admixture in the rare variant contribution to inflammatory bowel disease.Semantic proximity Read ↗

Parent-of-origin-environment interactions in case-parent triads with or without independent controls.Semantic proximity Read ↗

Genome-wide analysis of parent-of-origin interaction effects with environmental exposure (PoOxE): An application to European and Asian cleft palate trios.Semantic proximity Read ↗

Genomic Insights Into Inflammatory Bowel Disease in United States Hispanic Participants: An Ancestry-Focused Study.Semantic proximity Read ↗

Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians.Semantic proximity Read ↗

Enhanced Contribution of HLA in Pediatric Onset Ulcerative Colitis.Semantic proximity Read ↗

Established genetic risk factors do not distinguish early and later onset Crohn's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.