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Article

Identification of Phe187 as a crucial dimerization determinant facilitates crystallization of a monomeric retroviral integrase core domain.

Structure (London, England : 1993) - 7 Oct 2014

Galilee Meytal, Alian Akram

Abstract excerpt

Retroviral DNA integration into the host genome is mediated by nucleoprotein assemblies containing tetramers of viral integrase (IN). Whereas the fully active form of IN comprises a dimer of dimers, the molecular basis of IN multimerization has not been fully characterized. IN has consistently been crystallized in an analogous dimeric form in all crystallographic structures and experimental evidence as to the...

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PMID: 25199694
DOI: 10.1016/j.str.2014.08.001

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