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Automated Analysis of Cryptococcal Macrophage Parasitism Using GFP-Tagged Cryptococci

31 Dec 2010

Abstract excerpt

The human fungal pathogens Cryptococcus neoformans and C. gattii cause life-threatening infections of the central nervous system. One of the major characteristics of cryptococcal disease is the ability of the pathogen to parasitise upon phagocytic immune effector cells, a phenomenon that correlates strongly with virulence in rodent models of infection. Despite the importance of phagocyte/Cryptococcus interactions...

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PMID: 21209844
DOI: 10.1371/journal.pone.0015968

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