Article
Potential role for PAD2 in gene regulation in breast cancer cells.
PloS one - 1 Jan 2012
Cherrington Brian D, Zhang Xuesen, McElwee John L, Morency Eric, Anguish Lynne J, Coonrod Scott A
Abstract excerpt
The peptidylarginine deiminase (PAD) family of enzymes post-translationally convert positively charged arginine residues in substrate proteins to the neutral, non-standard residue citrulline. PAD family members 1, 2, 3, and 6 have previously been localized to the cell cytoplasm and, thus, their potential to regulate gene activity has not been described. We recently demonstrated that PAD2 is expressed in the...
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