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Article

Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice.

BMC musculoskeletal disorders - 5 May 2016

Suzuki Akari, Kochi Yuta, Shoda Hirofumi, Seri Yu, Fujio Keishi, Sawada Tetsuji, Yamada Ryo, Yamamoto Kazuhiko

Abstract excerpt

BACKGROUND: Peptidylarginine deiminase type 4 (PADI4) has been identified as a susceptibility gene for rheumatoid arthritis (RA) by genome-wide association studies. PADI4 is highly expressed in the bone marrow, macrophages, neutrophils, and monocytes. Peptidyl citrulline is an interesting molecule in RA because it is a target antigen for anti-citrullinated peptide antibodies, and only PADs (translated proteins...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27150598
DOI: 10.1186/s12891-016-1055-2
PMCID: PMC4858923

Genes

PADI4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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