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Article

Behavioral effects of Rho GTPase modulation in a model of Alzheimer's disease.

Behavioural brain research - 15 Jan 2013

Musilli Marco, Nicolia Vincenzina, Borrelli Sonia, Scarpa Sigfrido, Diana Giovanni

Abstract excerpt

Small GTPases of the Rho family, including Rho, Rac and CDC42 subfamilies, play key role in neural connectivity and cognition. The pharmacological modulation of these regulatory proteins is associated with enhancement of learning and memory. We sought to determine whether the modulation of cerebral Rho GTPases may correct behavioral disturbances in a mouse model of Alzheimer's disease (AD). TgCRND8 mice show...

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Source

Identifiers

PMID: 23026376
DOI: 10.1016/j.bbr.2012.09.043

Genes

CDC42

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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