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Article

Wheel-running in a transgenic mouse model of Alzheimer's disease: protection or symptom?

Behavioural brain research - 26 Jun 2008

Richter Helene, Ambrée Oliver, Lewejohann Lars, Herring Arne, Keyvani Kathy, Paulus Werner, Palme Rupert, Touma Chadi, Schäbitz Wolf-Rüdiger, Sachser Norbert

Abstract excerpt

Several studies on both humans and animals reveal benefits of physical exercise on brain function and health. A previous study on TgCRND8 mice, a transgenic model of Alzheimer's disease, reported beneficial effects of premorbid onset of long-term access to a running wheel on spatial learning and plaque deposition. Our study investigated the effects of access to a running wheel after the onset of Abeta pathology...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18342378
DOI: 10.1016/j.bbr.2008.02.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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